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Materialise aMace Technology Used for Pelvic Reconstruction in Cancer Patients

Periacetabular reconstruction after tumor resection

Approximately 8-20% of all bone tumors occur in the pelvis, one third of which are malignant. For these challenging bone defects particularly, a patient-specific solution is necessary. After three years of anatomical examinations, biomechanical experiments, further analysis of modularity and one-time surgeries, innovation prevailed.

Thanks to Materialise aMace technology, the orthopedic teams turned what were very challenging bone defects into successful periacetabular reconstructions. With the support of biomedical engineers and both clinical groups from Copenhagen, Denmark and Basel Switzerland, the new aMace Tumor Reconstruction System was tested in five patients with periacetabular defects.

Left to right: Scaffold with modular plates and screws, patient-specific resection guides, test models, patient-specific drilling guides, bone model

Five successful surgeries

For two of the patients, a two-step procedure of the aMace implant initially was performed. In association with Materialise, the medical teams planned the surgery with 3D virtual imaging, starting with MRI and CT scans of the tumor. Then, the tumor was removed using patient-specific resection guides. Ten days later, based on a CT scan of the resected bone, the final aMace and custom plates were designed and 3D printed, and the surgical team performed the final surgery. In the three other cases, a one-time procedure with direct aMace implantation was performed thanks to patient specific cutting guides.

Positive results

With the use of pre-operative planning, patient-specific guides and implants, Dr. Krieg and his colleagues saw superior results in terms of fit, fixation and patient mobility compared to the current pelvic reconstruction methods. They also observed reduced infection risks by switching from a two-step to a one-time surgery, due to shorter operation times and faster healing of the wound thanks to using patient specific cutting guides from Materialise. Furthermore, the team reported shorter hospital stays and significantly lower costs for the last three patients.

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